Mitomycin C (MMC) and Unconventional Fractionation (V-Chart) in Advanced Head and Neck Cancer
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چکیده
منابع مشابه
Altered fractionation for head and neck cancer.
A conventional course of radiation for squamous cell carcinoma in the United States is generally 70 Gy in 7 weeks, with a once-daily dose of 1.8 to 2 Gy. This schedule has a modest success rate in curing head and neck cancer. The past several decades have seen numerous investigations into altering this schedule to optimize the results of radiation. Two approaches, founded on radiobiologic princ...
متن کاملAltered Fractionation for Head and Neck Cancer
Delivery of therapeutic radiation in multiple sessions, or fractions, has been practiced since the discovery of radiation’s potential to cure malignancies. Initially, this was done out of practical necessity: Radiation was delivered at a low dose rate, and the treatment sessions had to be repeated to obtain the desired effect. Technologic improvements eventually allowed for treatments in one se...
متن کاملHead and neck cancer: altered fractionation schedules.
Local control is paramount in the treatment of localized advanced head and neck cancer. Standard radiotherapy cures a high percentage of early tumors--more than 80% of the early laryngeal tumors--but fewer of the advanced tumors. Attempts have therefore been made to improve the therapeutic ratio by: A) hyperfractionation: reducing the dose per fraction to reduce late morbidity; the total dose i...
متن کاملA randomized study of accelerated fractionation radiotherapy with and without mitomycin C in the treatment of locally advanced head and neck cancer.
OBJECTIVES This single-institution study evaluates the feasibility of accelerated fractionation radiotherapy (AF) with and without mitomycin C (MMC) in the treatment of locally advanced head and neck cancer. PATIENTS AND METHODS Between May 1998 and October 2001, sixty patients with locally advanced stage III and IV of head and neck cancer were randomized into three treatment arms: (1) conven...
متن کاملQuality of life in head and neck cancer patients
Quality of life in head and neck cancer patients
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ژورنال
عنوان ژورنال: Acta Oncologica
سال: 1995
ISSN: 0284-186X,1651-226X
DOI: 10.3109/02841869509093973